PHOSOPLEX vitamins for bones.

bones of human leg

2008-02-29T08:59:00.000-08:00

Osteoporosis and related conditions
Osteoporosis is a common condition of elderly men and women. It is caused by lack of load-bearing exercise, ageing, and oestrogen deficiency. As oestrogen is manufactured in fat, it affects thin people more. Bones become thin, as there is a shortage of the organic scaffolding that holds calcium. Women patients can be treated with oestrogens, and both sexes are advised to take load-bearing exercise such as walking and running, but this is often not feasible and sufferers have to cope with spinal deformity (the dowager’s hump), increased risk of fractures, and pain.

Research on sheep showed that 20 minutes a day of mild vibration to their back legs for a year was harmless and significantly increased their bone density, and this finding could be used to improve the bone structure of osteoporotic patients1. Researchers have identified a gene, Alox15, which produces an enzyme affecting skeletal development in mice. It seems to stimulate a pathway that favours more fat deposition but less bone formation, and an experimental drug that blocks the pathway reduces bone loss2.

Amylin, a hormone made by the same pancreatic B-cells that produce insulin, prevents bone loss, and explains why people with early-onset diabetes are susceptible to osteoporosis, a finding that has therapeutic implications. Amylin-deficient mice have lowered bone weight3.

In 2003 it was suggested that there is an immunological component to osteoporosis, at least in mice. Oestrogen-related bone loss is associated with too many T-cells in the blood, and this is associated with oestrogen deficiency. T-cells produce tumour necrosis factor, which increase the number of osteoclasts, cells that break down bone (bone undergoes a constant cycle of formation and breakdown, but until recently no-one knew how this was regulated). In turn, T-cell regulation is kicked off by an immune system protein called interferon gamma4.

Rickets
Hypophosphataemia is an inherited form of rickets found in boys. It is caused by excessive phosphate excretion by the kidney, and a similar disease occurs in mice. Researchers have found that indomethacin, a widely-used anti-inflammatory painkiller, prevents this phosphate loss, and the drug is already being tested in children with the disease5.

Osteoarthritis
Osteoarthritis is a common condition in older people and is the most common reason for hip and knee replacement. It also causes painful swelling of the fingers. It has a genetic component and is more common in women. The earliest indication of the disease is a gradual loss of large molecules called proteoglycans from the surface of the joint cartilage resulting in a decrease in the mechanical strength of cartilage. At the same time, other cells proliferate and form clusters. Then cracks in the cartilage gradually develop and the cracks are filled with fibrous tissue, probably as a result of unsuccessful attempts by the cartilage cells to repair the cracks. Finally, bony structures, called osteophytes, are formed at the periphery of the joint. The end result is loss of joint function.

Using naturally occurring mutant mice with a defective collagen gene, scientists have identified a signalling molecule involved in osteoarthritis.

Although the causes of osteoarthritis are diverse, mutations in two types of collagens, type IX and XI, are linked to early-onset osteoarthritis. Mice with a mutation in type XI collagen have age-related osteoarthritis and scientists found that these mice had increased amounts of the protein called DDR2 in their knee joint cartilage. Inhibitors of DDR2 signalling may be useful as arthritis drugs6.

In March 2005, two research groups showed that shutting down a single gene can prevent cartilage destruction in a genetically modified mouse with osteoarthritis. During the human disease, the cartilage in the joints gradually breaks down and a key component of cartilage called aggrecan, which helps the tissue bear load and resist compression, is chewed up by enzymes of the ADAMTS or aggrecanase family. Mice that lack a part of one such enzyme, ADAMTS5 (aggrecanase-2), are largely protected from cartilage destruction. The studies are the first to show that mutations in a single gene can halt cartilage degradation, and suggest that drugs designed to inhibit the human form of ADAMTS5 might help fight osteoarthritis7,8.

Inflammatory joint disease
The inflammatory joint diseases include rheumatoid arthritis, ankylosing spondylitis, Sjogren’s syndrome, and lupus. There are some features and treatments that are common to all of these conditions. With the exception of ankylosing spondylitis, women are more often affected than men. Skin and other organs are often affected, and the conditions are now understood as being caused by autoimmunity – that is, the body attacking itself. All of these conditions have a genetic component. More specific details of research in these conditions are detailed below.

Modifying the immune response
Both types of immune cells, called B-cells and T-cells, take part in the attack on oneself that forms the autoimmune response. As these are also essential for fighting off infection, it is hard to damp them down without doing harm. In 2001 scientists found a molecule that does that in mice, and which works on both types of immune cell9. Another promising line of research comes from understanding and modifying T-cells, the white blood immune cells that attack joints inappropriately. This can be prevented in mice by blocking the cells’ response to low oxygen levels by inactivating a protein called HIF-1, a finding that could lead to the development of new treatment10. Another approach consists of making a ‘magic bullet’ that carries a toxic drug, doxorubicin, and targets only those T-cells that attack the joints11.

Research on mice explains why the severity of inflammation varies between individuals. Different types of a protein called RAGE (receptor for advanced glycation end-products) exist in joints, and RAGE binds to other proteins called S100/calgranulins. Inflammation can be greatly decreased by preventing this binding. RAGE may also be associated with other autoimmune genes12.

Protection and prevention
A natural constituent of cannabis, cannabidiol, which has no effect on mood or consciousness, may be useful for treating inflammatory joint disease; scientists have found that it protects mice from severe joint damage by suppressing key parts of their immune response13.

Rheumatoid arthritis
One line of research comes from studying the joints of patients with rheumatoid arthritis (RA), which have excessive amounts of an enzyme called synoviolin. When mice were genetically engineered to overproduce this enzyme they got the disease, and when they were engineered to underproduce it, they were protected from RA. Overproduction also impaired a process called apoptosis, whereby damaged or unwanted cells self-destruct14.

A study in rats found that a drug, M40403, mimicking superoxide dismutase (SOD), a naturally occurring compound in the body, halved the damaged to joints and reduced the amount of inflammation by over 70%15.

Injection of an antibody called anti-CD40 controls progression of the disease in mice with RA, and reduced pain and swelling. The antibody normally boosts the immune system, so the discovery is puzzling16. Another gene, that makes interleukin-13, when injected into mouse joints, reduced inflammation in RA mice and prevented it in normal mice17.

About 1 in 40 RA patients has a mutation in a gene called ZAP-70. Mice with this mutation have a type of T-cell that is normally lost during development, and suffer from RA, so studying them might help some patients18.

One of the more important discoveries in recent years is the finding, in 2001, that injections of a hormone called vasoactive intestinal peptide or VIP prevented joint swelling and destruction in mice, and the benefit stayed for some time after stopping injections19. This treatment is now being studied in human RA patients.

The most effective therapy in mice, to date, is the discovery in 2004 of an experimental agent that blocks the CD139 protein on the surface of T-cells and thereby decreases the production of destructive antibodies that damage the joint. Clinical trials are awaited with interest20.

Ankylosing spondylitis
Ankylosing spondylitis is an inflammatory disease of the tendons that link the vertebrae together. These gradually become ossified and the spine collapses, causing deformity. Patients often suffer additional arthritis in their arms and legs, and have disease in other organ systems. The disease is strongly genetic, but often triggered by infections. Mice with a defective copy of a gene called ank have a similar disease and it has now been discovered that this defective gene causes a shortage of a chemical, pyrophosphate in the joints. Humans have a similar gene, and the finding may lead to new approaches to treatment21.

Lupus
Lupus affects skin, joint, blood vessels and other organs and tissues. It has a genetic component, is often triggered by viruses, and can be life threatening. A similar disease occurs in a strain of mice, and recently – from 2003 onwards – this has generated results that have greatly increased the understanding of human disease.

There is a strain of mice with lupus, and these have been shown to lack an enzyme called Dnase1, which removes rubbish from cells22. Removal of an immune-system signalling protein, SLAM-associated protein, or SAP, also causes lupus23. In 2001 a lupus-causing gene was identified in mice. It causes a fault in an enzyme called alpha-mannosidase II24. Scientists now need to know more about how these substances interact.

Scientists have used gene therapy to prevent the development of lupus in mice by boosting levels of an immune system component. A receptor gene known as Fc acts like a gatekeeper, helping to maintain a healthy immune system instead of one that turns on itself, as is the case in autoimmune diseases.

In mice and in humans with lupus, production of the Fc receptor is reduced. Gene therapy reversed this and prevented the disease in a lupus-susceptible strain of mice, but not in untreated mice. The scientists expect their finding to apply to humans, since there seemed to be no serious adverse effects from the therapy in mice25.

A protein molecule that interferes with the site where antibodies act reduces the mortality in mice with genetic lupus from 80% down to 10%, and virtually eliminates kidney damage26, and a tranquilliser-like drug, Bz-423, reduces the incidence of renal complications by 85%27, as does an anti-cancer drug, SAHA28.

Lupus patients often have neuropsychiatric problems, and their memory is sometimes affected. Mice with lupus have shown why this might be: the immune system sends defensive antibodies into the brain and selectively kills memory cells. This effect can be blocked by the drug memantine, which is used for Alzheimer’s29.

Sjogrens syndrome
Patients with Sjogren’s syndrome not only have joint symptoms but also have dry eyes and insufficient saliva because the body’s immune system attacks moisture-producing glands. By studying a strain of mice with the disease, scientists have identified the protein, ICA69, which causes it. By removing the gene that produces the protein, scientists removed the tear gland disease and reduced the salivary disease. They have now produces a vaccine that stops disease progression30.

Phosoplex

2007-11-29T01:50:00.000-08:00

If you suffer from joint and cartilage pain caused by injury,years of participating in sports,aging or a chronic disease like arthritis then Phosoplex™ is exactly what you need. Phosoplex™ is simply the most powerful all natural and safe solution for joint lubrication,pain relief and the rebuilding of healthy cartilage. Phosoplex™ with its many mechanisms of action can give you back the lifestyle you once enjoyed. Phosoplex ™ is recommended for:

Individuals Suffering from Osteoarthritis
Tendonitis Symptoms and Pain
Lower Back Pain
Carpal Tunnel Syndrome
Muscle and Joint Pain and Soreness
Fibromyalgia
Overall Body Stiffness
Rheumatoid Arthritis
Injury Prevention Through the Strengthening of Joint Cartilage
Maintenance of Joint Lubrication
Easing Everyday Wear and Tear on Joints
Athletes Who are Involved in Intense Training Programs

Phosoplex ™ is the most complete joint health supplement available today. Phosoplex™ helps reduce joint pain and stiffness with 100% all natural and safe ingredients. Phosoplex goes way beyond simple glucosamine and chondroitin formulas with clinically substantiated ingredients that are readily bioavailable and easily absorbed. Phosoplex™'s multiple mechanisms of action are superior to that of all other formulas aiding overall joint health. Phosoplex™ is simply the best Joint Care product on the market today.

coral calcium

2007-09-25T14:39:00.000-07:00

coral calcium

Coral LLC is the leader supplier of Above Sea Coral

Our Coral Calcium products include: Raw / Bulk Coral Powder, Coral Complex3, Eco Pure Powder, Coral Pure, Coral White Toothpaste, Coral Stress with Kava Kava, Coral Memory Support.

Coral Calcium is a formula designed to alkalize your body and raise the body pH level, increase bone density, and inhibit bone loss.

Safety Information
Pregnant or lactating women should consult a doctor before using any product. Avoid the product if you have or have had allergies to seafood. Do not exceed recommended dose. Consult doctor before use if you have, or have had kidney stones, kidney disease, sarcoidosis or hyperparathyroidism or if you are taking any prescription medications including hormone replacement therapy. Discontinue use and consult your doctor if any adverse reactions occur, including gastrointestinal discomfort. Not intended for use by persons under the age of 18.

Ingredients
Rice Powder, Gelatin, Silica, Vegetable Magnesium Stearate.

Directions
For adults, Take two (2) or more calcium capsules per day, preferably with meals, depending on your calcium needs.

Grapefruit become younger and help strengthen bones

2007-09-24T08:23:00.000-07:00

Grapefruit - unique jugs, practically indispensable for women. The aroma of grapefruit makes a woman five years younger, and the consumption of juice - excellent development of osteoporosis prevention.

The greatest characteristic aroma of grapefruit discovered neurologist and psychiatrist Alan Hirsch, director of Research Foundation smell and taste in Chicago. After several experiments, he found that the smell of grapefruit makes women in the eyes of men at the age of 5-6 years. Scientific experiments conducted with the participation of volunteers: middle-aged women putt on different aromas, including broccoli, banana, mint, lavender and so on. But none of those smells male perception has not changed. None other than the smell of grapefruit. At the same time, the scents that have impact on how women evaluate age men, were found. "To Do men more susceptible flavor women, or women are making skilful determine the age that nothing could deceive them" - a summary of Hirsch.

Meanwhile, scientists from Texas A & M University found that regular consumption of orange and grapefruit juice prevents the development of osteoporosis. "We found that Plum and orange juice increased the activity of antioxidants that increase bone density" - said one of the authors of the study Bhimu Patil.

Antioxidants - vitamins, minerals and other natural components - hinder the development of cancer, cardiovascular disease and stroke, scientists believe. In citrus fruit contains about 400 active ingredients - which one of these components contributes to the strength of bones, exactly unknown, but the researchers suggest that such a substance is limonoid.

Recall osteoporosis - a disease characterized by progressive decrease in bone density. In most cases, the disease progresses after 50 years, the most frequent manifestation serve her neck fractures femur, vertebrae or tubular bones.

Antioxidant multi vitamin - Vitamin A & D

2007-08-26T00:08:00.000-07:00

This multivitamins are veru useful.
Vitamin A combinations are used to prevent or to treat a calcium deficiency;
Vitamin D combinations are responsible for cell division and bone growth.

Drug Class and Mechanism

Vitamin A is found in food from animal sources and needed for cell division, growth of bones, skin, and male and female reproductive organs night vision and. In pregnant women vitamin A is necessary for the growth of a healthy fetus.
Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.
Buy Antioxidant multi vitamin here